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Western Journal of Nursing Research, Vol. 22, No. 6, 736-748 (2000)
DOI: 10.1177/01939450022044719

The Effect of a High-Fat Diet and Exercise on the Expression of Genetic Obesity

Bonnie L. Metzger

University of Michigan, School of Nursing

Patricia A. Jarosz

University of Michigan, School of Nursing

Samar Noureddine

University of Michigan, School of Nursing

In the United States, there are 300,000 obesity-related premature deaths each year. Furthermore, no current obesity treatment program results in consistent weight reductions. Obesity is thought to be caused by complex genetic-environmental interactions. We studied the effect of two environmental factors, high-fat diet and non-weight-bearing exercise, on obesity expression. Young adult, female, genetically obese (fa/fa) rats (n = 52) and their lean (Fa/fa) littermates (n = 24) were studied using an experimental 2x2x2 factorial design (diet type, genetics, and exercise). Repeated measures ANOVA and secondarily stepwise regressions were used to analyze the data. The authors discovered that the effect of appetite on obesity expression is more limited than expected, and there may be critical stages when obesity expression is amenable to environmental modification.


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[Abstract] [PDF]